Best Max-CoQ10
Supplement Facts

Supplement Facts
Serving Size: 1 Softgel
Serving per Container: 30

Amount per Serving                                         % Daily Value

Best Coenzyme Q10                                               100mg                      *
                               

*Daily Value not established

Other Ingredients: Soybean Oil, Gelatin, Glycerin, Purified Water & Titanium Dioxide

Coenzyme Q10**

Coenzyme Q-10 (CoQ-10) is a vitamin-like substance found throughout the body, but especially in the heart, liver, kidney, and pancreas. It is eaten in small amounts in meats and seafood. Its primary functions include activity as an antioxidant, a membrane stabilizer, and as a cofactor in many metabolic pathways, particularly in the production of ATP (the cell energy) in oxidative respiration (1, 2, 3, 4, 5, 6).*

Coenzyme Q-10 levels are highest during the first 20 years of life and decline with age. At age 80, coenzyme Q-10 levels may be lower than at birth.

Coenzyme Q-10 might help increase energy. This is because coenzyme Q-10 has a role in producing ATP, a molecule in body cells that functions like a rechargeable battery in the transfer of energy.

Coenzyme Q-10 may be helpful for people with diseases for which coenzyme Q-10 levels are often low, including congestive heart failure (CHF), hypertension, periodontal disease, certain muscular diseases, and AIDS (1, 4).*

Coenzyme Q-10 was first identified in 1957. The “Q-10” refers to the chemical make-up of the substance. These days coenzyme Q-10 is used by millions of people in Japan for heart disease, especially congestive heart failure. Coenzyme Q-10 is also used extensively in Europe and Russia (6). *

Some benefits of Co-Q10:

1. Helpful for congestive heart failure (CHF). There is some evidence (though controversial) that it might be helpful when taken in combination with other heart failure medications and treatments. Adding oral coenzyme Q-10 to conventional treatments seems to improve quality of life, decrease hospitalization rates, and decrease symptoms of heart failure such as dyspnea, peripheral edema, enlarged liver, and insomnia in patients with mild to severe (New York Heart Association Class II-IV) CHF (7, 3, 8, 6,9, 10). *

2. Help decrease the risk of heart attack (myocardial infarction, MI). When coenzyme Q-10 started within 72 hours of heart attack and taken for one year, coenzyme Q-10 appears to significantly lower the risk of heart-related events including non-fatal MI and cardiac death (6, 11).*

3. Helpful for high blood pressure (hypertension). Taking coenzyme Q-10 by itself or along with other medications for treating high blood pressure seems to help lower blood pressure (6, 12, 13, 14).*

4. Improve immune function. Taking coenzyme Q-10 orally seems to improve immune function in people with HIV/AIDS (15, 24).*

5. Help reduce muscle pain caused by statins (the cholesterol lowing drugs) Statins, a class of drugs used to lower cholesterol, can sometimes cause muscle pain. There is some evidence that taking coenzyme Q-10 might reduce this pain. In a preliminary clinical trial, patients with statin-induced myopathy who took coenzyme Q10 100 mg daily had significantly reduced pain intensity compared to baseline and compared to a vitamin E control after 30 days of treatment (16). A review study found that eight out of nine controlled clinical trials with Statins resulted in significant depletions of Co Q-10 levels (25).*

6. Help increase life span. This idea got started because coenzyme Q-10 levels are highest in the first 20 years of life. By age 80, coenzyme-Q10 levels can be lower than they were at birth. Some people thought that restoring high levels of coenzyme-Q10 late in life might cause people to live longer. The idea works in bacteria, in some kinds of bacteria, coenzyme Q-10 supplements seem to prolong life (6, 17).*

7. Help Migraine headache. Taking coenzyme Q-10 by mouth seems to help prevent migraine headaches. Studies show it can decrease the frequency of headaches by about 30% and the number of days with headache-related nausea by about 45% in adults (18, 19). Taking coenzyme Q-10 also appears to reduce migraine frequency in children who have low levels of coenzyme Q-10(20). It can take up to 3 months for significant benefit.*

8. Help Parkinson's disease. Some evidence shows that taking high doses of coenzyme Q-10, 300-2400 mg/day slows functional decline in people with early Parkinson's disease (21, 22). This effect appears to be dose dependent (6, 21).*

9. Help infertility. Preliminary research shows that infertile men with idiopathic asthenozoospermia who take coenzyme Q-10 200 mg/day have increased sperm motility after 6 months of treatment (23).*

* These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

Coenzyme Q10**

1.  Greenberg S, Frishman WH. Coenzyme Q10: a new drug for cardiovascular disease. J Clin Pharmacol 1990;30:596-608.
2.   Watson PS, Scalia GM, Galbraith A, et al. Lack of effect of coenzyme Q on left ventricular function in patients with congestive heart failure. J Am Coll Cardiol 1999;33:1549-52.
3.   Hofman-Bang C, Rehnqvist N, Swedberg K, et al. Coenzyme Q10 as an adjunctive treatment of congestive heart failure. J Card Fail 1995;1:101-7.
4.  Pizzorno JE, Murray MT, eds. Textbook of Natural Medicine. 2nd ed. New York: Churchill Livingston, 1999.
5.  Turunen M, Olsson J, Dallner G. Metabolism and function of coenzyme Q. Biochim Biophys Acta 2004;1660:171-99.
6.  Jelilin JM, Gregory PJ, et al. Pharmacist’s Letter/Prescriber’s Letter Natural Medicines Comprehensive Database. 12th ed . Stockton, CA: Therapeutic Research Faculty; 2009:pg471-477.
7.   Morisco C, Trimarco B, Condorelli M. Effect of coenzyme Q10 therapy in patients with congestive heart failure: A long-term, multicenter, randomized study. Clin Investig 1993;71:S134-6.
8.   Baggio E, Gandini R, Plauncher AC, et al. Italian multicenter study on the safety and efficacy of coenzyme Q10 as adjunctive therapy in heart failure. CoQ10 Drug Surveillance Investigators. Mol Aspects Med 1994;15 Suppl:S287-94.
9 .  Soja AM, Mortensen SA. Treatment of congestive heart failure with coenzyme Q10 illuminated by meta-analyses of clinical trials. Mol Aspects Med 1997;18:S159-68.
10.   Berman M, Erman A, Ben-Gal T, et al. Coenzyme Q10 in patients with end-stage heart failure awaiting cardiac transplantation: a randomized, placebo-controlled study. Clin Cardiol 2004;27:295–9.
11.   Singh RB, Neki NS, Kartikey K, et al. Effect of coenzyme Q10 on risk of atherosclerosis in patients with recent myocardial infarction. Mol Cell Biochem 2003;246:75-82.
12.   Langsjoen P, Willis R, Folkers K. Treatment of essential hypertension with coenzyme Q10. Mol Aspects Med 1994;S265-72.
13.   Singh RB, Niaz MA, Rastogi SS, et al. Effect of hydrosoluble coenzyme Q10 on blood pressures and insulin resistance in hypertensive patients with coronary artery disease. J Hum Hypertens 1999;13:203-8.
14.   Hodgson JM, Watts GF, Playford DA, et al. Coenzyme Q10 improves blood pressure and glycaemic control: a controlled trial in subjects with type 2 diabetes. Eur J Clin Nutr 2002;56:1137-42.
15.   Folkers K, Hanioka T, Xia LJ, et al. Coenzyme Q10 increases T4/T8 ratios of lymphocytes in ordinary subjects and relevance to patients having the AIDS related complex. Biochem Biophys Res Commun 1991;176:786-91.
16   Caso G, Kelly P, McNurlan MA, Lawson WE. Effect of coenzyme Q10 on myopathic symptoms in patients treated with statins. Am J Cardiol 2007;99:1409-12.
17.   Ishii N, Senoo-Matsuda N, Miyake K, et al. Coenzyme Q10 can prolong C. elegans lifespan by lowering oxidative stress. Mech Ageing Dev 2004;125:41-6..
18.   Rozen TD, Oshinsky ML, Gebeline CA, et al. Open label trial of coenzyme Q10 as a migraine preventive. Cephalalgia 2002;22:137-41.
19.   Sandor PS, Di Clemente L, Coppola G, et al. Efficacy of coenzyme Q10 in migraine prophylaxis: A randomized controlled trial. Neurology 2005;64:713-5.
20.  Hershey AD, Powers SW, Vockell AB, et al. Coenzyme Q10 deficiency and response to supplementation in pediatric and adolescent Migraine. Headache 2007;47:73-80.
21.   Shults CW, Oakes D, Kieburtz K, et al. Effects of coenzyme Q10 in early Parkinson disease: evidence of slowing of the functional decline. Arch Neurol 2002;59:1541-50.
22.  The NINDS NET-PD Investigators. A randomized clinical trial of coenzyme Q10 and GPI-1485 in early Parkinson disease. Neurology 2007;68:20-8.
23.  Balercia G, Mosca F, Mantero F, et al. Coenzyme Q10 supplementation in infertile men with idiopathic asthenozoospermia: an open, uncontrolled pilot study. Fertil Steril 2004;81:93-8.
24.   Folkers K, Langsjoen P, Nara Y, et al. Biochemical deficiencies of coenzyme Q10 in HIV-infection and exploratory treatment. Biochem Biophys Res Commun 1988;153:888-96.
25.   Langsjoen PH, et al. Biofactors. 2003; 18(1-4): 101-11
**  Jellin JM, Gregory PJ, et al. Pharmacist’s letter/Prescriber’s Letter Natural Medicines Comprehensive Database. 12th ed. Stockton, CA: Therapeutic Research Faculty; 2009: P471-476.

1.     : What are the health benefits of taking CoQ10?

CoQ10 is responsible for more than 90% of energy production within our body. CoQ10 levels decline with age; at age 80, CoQ-10 levels may be lower than at birth. It is helpful to begin supplementing your diet with CoQ10 for overall health, especially for those people with low level of CoQ10, including congestive heart failure (CHF), hypertension, periodontal disease, certain muscular diseases, and AIDS. CoQ10 is the essential nutrient for supporting your heart's health.*

2.     Is it best to take the CoQ10 with meal?

Yes, it is always best to take your nutritional supplements with a meal. This allows your body to absorb the nutrients more efficiently and with a greater degree of tolerance.

3.     How many CoQ10 capsules should I take a day?

For adult, take 1-2 capsule(s) with meal, 1-2 times a day.

* These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.